Glossary

Statistical Significance

Statistical significance is a concept in inferential statistics that determines whether observed results are unlikely to have occurred by random chance alone. It involves testing a null hypothesis and calculating the probability (p-value) of obtaining results at least as extreme as those observed if the null hypothesis were true. Results are typically considered statistically significant when the p-value falls below a predetermined significance level, commonly 0.05.

Context and Usage

Statistical significance is widely used in scientific research, clinical trials, social sciences, and data analysis across academic, medical, and industrial settings. Researchers apply statistical significance testing to evaluate experimental results, compare treatment effects, validate hypotheses, and make informed decisions based on quantitative data. The concept is fundamental to hypothesis testing methodology and helps distinguish meaningful patterns from random variation in data.

Common Challenges

Common challenges include misunderstanding the distinction between statistical significance and practical importance, as results can be statistically significant yet have minimal real-world impact. P-values are frequently misinterpreted as probabilities that hypotheses are true, rather than as measures of data compatibility with the null hypothesis. Statistical significance can be influenced by sample size, with large samples detecting trivial differences as significant, while small studies may miss important effects. Issues such as p-hacking, multiple comparisons, and publication bias can lead to spurious significant findings.

Related Topics: hypothesis testing, p-value, confidence interval, null hypothesis, type I error, type II error, sample size, effect size

Jan 30, 2026

Reviewed by Dan Yan